How Prulifloxacin 600mg Works

The active component of Steris Healthcare’s PRULITECH 600, a powerful broad-spectrum antibiotic from the fluoroquinolone class, is prulifloxacin 600 mg. After oral administration, this prodrug quickly transforms into ulifloxacin, its physiologically active form. The bacterial enzymes DNA gyrase and topoisomerase IV, which are necessary for DNA replication and cell division, are targeted by and inhibited by ulifloxacin. Prulifloxacin inhibits the growth and multiplication of bacteria by blocking these enzymes, which causes quick bacterial cell death and infection clearance.

PRULITECH 600’s enhanced bioavailability means it achieves high concentrations at infection sites, enabling fast symptom relief and improved clinical outcomes. With once-daily dosing, it offers convenience and compliance, especially valuable in outpatient infection management.​

What Are the Benefits of Prulifloxacin 600mg?

• Powerful activity against a broad range of gram-negative and gram-positive bacteria.
• Effective for respiratory tract infections (such as bronchitis and pneumonia), urinary tract infections (including cystitis), and gastrointestinal infections (like infectious diarrhea).​
• Useful in complicated or stubborn infections resistant to older antibacterial agents.
• Once-daily oral dosing supports easy adherence for patients.
• High tissue penetration gives it an advantage for skin/soft tissue or deep-seated infections.

Key Benefits of PRULITECH 600

• Rapid symptom relief due to potent antibacterial action.
• Convenient dosing—just one tablet daily.
• Good tolerability with relatively low rates of gastrointestinal side effects versus older fluoroquinolones.​
• Demonstrated safety in patients with mild to moderate renal impairment (dose adjustment advised for severe cases).​
• Reduced risk of bacterial resistance compared to narrow-spectrum antibiotics.

Side Effects of Prulifloxacin 600mg

Though PRULITECH 600 is generally well tolerated, all fluoroquinolones may trigger side effects.

Common Side Effects of Prulifloxacin 600mg

• Nausea or vomiting
• Diarrhea
• Headache or dizziness
• Abdominal discomfort or bloating
• Mild insomnia or nervousness

These side effects are often temporary and resolve with completion of the course or supportive care.​

Serious Side Effects of Prulifloxacin 600mg

• Tendon inflammation or rupture (especially in elderly or those on corticosteroids)
• Severe allergic reactions—rash, itching, swelling, or difficulty breathing
• Photosensitivity (higher risk of sunburn)
• Peripheral neuropathy (tingling or numbness in hands/feet)
• Liver enzyme abnormalities or rare hepatic dysfunction
• Increased risk of seizures in those with underlying CNS disorders​

Promptly report any signs of tendon pain, swelling, severe diarrhea, jaundice, or allergic reaction to your doctor.

Available Substitute for PRULITECH 600

• Other fluoroquinolone antibiotics: Ciprofloxacin, levofloxacin, ofloxacin, norfloxacin, moxifloxacin, etc.
• For patients with fluoroquinolone intolerance: beta-lactams (amoxicillin-clavulanate), cephalosporins, macrolides (azithromycin, clarithromycin) depending on infection site and bacterial susceptibility.​
• Substitutes should only be chosen on a physician’s recommendation based on infection type, resistance profile, and patient history.

Dosage Guidelines for Prulifloxacin 600mg

• Standard adult dose: 600 mg once daily, preferably at the same time each day.
• The tablet should be swallowed whole with or after a meal, not split or crushed.​
• Duration of treatment varies: 5–10 days depending on infection severity and type.
• In severe renal impairment, dose may need to be reduced to 300 mg daily.​
• Always complete the full course of therapy, even if symptoms improve earlier.

Precautions & Warnings

• Avoid if allergic to prulifloxacin or other quinolones.
• Use with caution in patients with a history of tendon disorders, seizures, or central nervous system diseases.
• Not recommended for children, adolescents, pregnant, or breastfeeding women unless advised by a physician.​
• Concomitant NSAIDs, corticosteroids, or certain antacids (containing magnesium/aluminum) may increase risk of side effects or reduce drug absorption—separate doses by at least 2 hours.
• May rarely cause abnormal heart rhythms (QT prolongation), so caution in those with a history of arrhythmia.
• Protect from sunlight, as prulifloxacin may increase skin sensitivity to UV.
• Regular monitoring of liver and kidney function advisable for those on prolonged therapy.

Mechanism of Action and Composition

Prulifloxacin 600mg acts by inhibiting bacterial DNA gyrase and topoisomerase IV. These enzymes are vital for the supercoiling, replication, and repair of bacterial DNA, which are required steps for bacterial division and survival. Inhibition ultimately leads to bacterial cell death, making PRULITECH 600 a bactericidal agent.​

INDICATIONS, EFFICACY, AND CLINICAL EVIDENCE

• Indications: PRULITECH 600 is indicated for urinary tract infections, respiratory tract infections, gastrointestinal (GI) infections, skin and soft tissue infections, and select sexually transmitted diseases.
• Efficacy: Numerous clinical studies support the effectiveness of prulifloxacin 600mg for both mild and moderate infections, with a comparable safety and success rate to other modern fluoroquinolones.​
• Clinical evidence: Clinical trials demonstrated rapid improvement in symptoms and high rates of bacterial eradication. Its pharmacokinetic profile permits effective concentrations in urine, lung, gastrointestinal, and soft tissue compartments, supporting its broad infectious disease use.​

Frequently Asked Questions

Q: What is the main use of PRULITECH 600 (Prulifloxacin 600mg)?
A: It treats a variety of bacterial infections, most commonly those involving the urinary tract, lungs, stomach, and skin.​

Q: How is PRULITECH 600 taken?
A: Take one tablet (600mg) once daily, with food, at the regular time prescribed by your doctor.

Q: What if I miss a dose?
A: Take as soon as you remember, but skip if it is nearly time for your next dose. Do not double doses.​

Q: Can it be used by children or pregnant women?
A: Generally not recommended; use only when advised by a healthcare professional.

Q: How much does PRULITECH 600 cost in India?
A: Prices may vary, but Steris Healthcare aims to offer affordable options. Confirm with local pharmacy for exact rates.

Q: Are there dietary restrictions?
A: Avoid antacids or supplements with iron, magnesium, or aluminum within 2 hours of taking prulifloxacin. Protect skin from intense sunlight.

Conclusion

PRULITECH 600 (Prulifloxacin 600mg) from Steris Healthcare is a modern broad-spectrum antibiotic designed to tackle a range of bacterial infections efficiently and safely. Its unique pharmacological profile ensures powerful action at infection sites, rapid bacterial clearance, and once-daily convenience. While the majority tolerate it well, users should remain alert for rare but serious side effects, follow dosing instructions precisely, and complete the course as prescribed for best results.​

About Steris Healthcare

Steris Healthcare is a leading name in specialty pharmaceuticals, offering advanced solutions like PRULITECH 600 for infectious diseases. Committed to quality, accessibility, and patient safety, Steris continues to set standards in emerging and super-specialty therapy areas.