Bosentan 62.5 mg – Uses, Dosage, and Benefits

Introduction

Bosentan 62.5 mg tablet, marketed as BOSENTIME 62.5 by Steris Healthcare Pvt Ltd, is a prescription medication used for managing pulmonary arterial hypertension (PAH) — a life-threatening condition involving high blood pressure in the lungs’ arteries. As an endothelin receptor antagonist, Bosentan works by relaxing pulmonary blood vessels, improving blood flow, and enhancing exercise capacity and quality of life for patients.

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What is Bosentan 62.5 mg Tablet?

BOSENTIME 62.5 contains bosentan, a dual endothelin receptor antagonist that blocks endothelin-1’s vasoconstrictive effects. By dilating blood vessels in the lungs, it reduces pulmonary arterial pressure, easing the workload on the heart. The 62.5 mg dose serves as a starting or maintenance dose depending on patient response.

Steris Healthcare Pvt Ltd ensures high-quality manufacturing standards compliant with regulatory guidelines to deliver safe and effective Bosentan tablets to patients.

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Therapeutic Uses of BOSENTIME 62.5 Tablet

• Pulmonary Arterial Hypertension (PAH): Improves exercise capacity and slows progression of PAH.
• Eisenmenger’s Syndrome: Manages PAH secondary to congenital heart defects.
• Other Pulmonary Hypertension Types: Prescribed under specialist supervision.
• Symptom Relief: Reduces shortness of breath, fatigue, and chest pain associated with PAH.

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How Does BOSENTIME Work?

Bosentan blocks ETA and ETB endothelin receptors, preventing endothelin-1 from causing blood vessel constriction. This leads to:

• Pulmonary artery dilation
• Reduced vascular resistance
• Lower pulmonary blood pressure
• Improved oxygen transport and heart function

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Composition of BOSENTIME 62.5 Tablet

• Active Ingredient: Bosentan 62.5 mg
• Inactive Ingredients: Formulated with pharmaceutical-grade excipients to ensure stability, bioavailability, and patient safety.

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Dosage and Administration

• Initial Dose: 62.5 mg twice daily for 4 weeks
• Maintenance Dose: Typically increased to 125 mg twice daily, as tolerated
• Route: Oral administration with or without food
• Monitoring: Liver function tests and blood counts are essential during treatment
• Adherence: Follow physician’s prescription strictly to ensure optimal outcomes

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Precautions and Contraindications

• Liver Toxicity: Frequent liver function monitoring required
• Pregnancy: Contraindicated due to risk of fetal harm; effective contraception mandatory
• Drug Interactions: Inform your doctor about all medications, as bosentan may interact with cyclosporine, glyburide, and others
• Contraindications: Severe liver impairment and hypersensitivity to bosentan
• Caution: Use with care in patients with heart failure or low blood pressure

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Common Side Effects

• Headache
• Flushing
• Nasal congestion
• Anemia
• Elevated liver enzymes
• Fluid retention
• Fatigue and dizziness
• Nausea

Report any signs of liver damage or severe side effects immediately.

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Safe Use Guidelines

• Take BOSENTIME as prescribed without missing doses
• Attend all scheduled lab tests and follow-up appointments
• Avoid alcohol and substances harmful to the liver
• Maintain effective contraception during treatment
• Do not stop medication abruptly without consulting your healthcare provider

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Who Should Use BOSENTIME 62.5?

• Adults diagnosed with PAH or Eisenmenger’s syndrome
• Patients experiencing symptoms like breathlessness and fatigue due to PAH
• Those under specialist medical supervision with regular monitoring

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Frequently Asked Questions (FAQs)

Q1. What is BOSENTIME 62.5 used for?
A: It is used to treat pulmonary arterial hypertension, improving exercise tolerance and symptoms.

Q2. How quickly does bosentan work?
A: Symptom improvement can be seen in weeks, with maximum benefits over months.

Q3. Is BOSENTIME safe during pregnancy?
A: No, it is contraindicated due to risk of serious fetal harm.

Q4. What monitoring is needed?
A: Regular liver function tests and blood counts to monitor for side effects.

Q5. Can bosentan cause side effects?
A: Yes, including headache, liver enzyme elevation, anemia, and fluid retention.

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Conclusion

BOSENTIME 62.5 mg Tablet by Steris Healthcare Pvt Ltd is a vital medication for patients battling pulmonary arterial hypertension. Its scientifically backed mechanism helps dilate lung arteries, easing symptoms and improving quality of life. With careful medical supervision, regular monitoring, and adherence to prescribed dosage, BOSENTIME offers an effective therapeutic option in managing PAH and related conditions safely.