Medicine information
उपयोग
CARDULES ISMN 10 (Isosorbide Mononitrate 10 mg Tablets) by Steris Healthcare delivers a precise 10 mg dose of Isosorbide Mononitrate for targeted cardiovascular support. As an active organic nitrate metabolite, it works by directly dilating vascular smooth muscle, reducing the workload on the heart, and ensuring adequate oxygen supply to the myocardium during physical exertion or stress. Note on Active Composition: While Isosorbide Mononitrate (ISMN) provides a direct, highly bioavailable active drug profile, it is commonly prescribed in lower 10 mg doses for initial titration, step-down maintenance, or combination cardiac therapies. Key Uses & Clinical Benefits: Angina Pectoris Prophylaxis: Effectively prevents and manages chest pain and tightness caused by ischemia or narrowed coronary arteries. Reduces Cardiac Oxygen Demand: Promotes venous and arterial vasodilation, lowering cardiac preload and systemic vascular resistance (afterload). Smooth Hemodynamic Adjustment: Low 10 mg strength allows physicians to customize dosage titration, minimizing initial nitrate headaches while achieving optimal therapeutic efficacy. Adjunctive Heart Failure Management: Helps lower ventricular filling pressures when used in combination regimens for managing chronic heart failure. Improves Exercise Tolerance: Helps patients with coronary artery disease perform daily physical activities with reduced risk of exertional chest discomfort. How CARDULES ISDN 10 Works: Isosorbide Mononitrate is converted in vascular smooth muscle cells to generate Nitric Oxide (NO). Nitric oxide stimulates the enzyme guanylate cyclase, elevating intracellular cyclic Guanosine Monophosphate (cGMP). This relaxes vascular smooth muscle, dilating veins and arteries to decrease venous return to the heart and reduce myocardial wall tension.
कैसे उपयोग करें
Take 1 tablet of CARDULES ISDN 10 two times daily (or as prescribed by your cardiologist or physician). To prevent nitrate tolerance, administer doses with an asymmetrical schedule (for example, taking doses 7 to 8 hours apart, such as at 8:00 AM and 3:00 PM) to ensure a daily "nitrate-free interval" during rest/sleep hours. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet unless advised by your doctor.
भंडारण
Store in a cool, dry, and dark place away from direct sunlight, heat, and moisture. Maintain at a controlled room temperature below 30°C. Keep out of reach and sight of children.
