Medicine information
उपयोग
CARDULES ISDN 5 by Steris Healthcare delivers 5 mg of Isosorbide Dinitrate, a proven organic nitrate vasodilator. Designed for flexible dosing and rapid clinical action, CARDULES ISDN 5 reduces cardiac workload and relieves exertional chest tightness by dilating both arterial and venous blood vessels, making it an invaluable asset in daily anti-anginal therapy and cardiac care. Key Ingredients & Clinical Benefits: Isosorbide Dinitrate (5 mg): An organic nitrate that undergoes metabolic conversion to release nitric oxide (NO) within vascular smooth muscle cells. It relaxes peripheral veins and coronary arteries, decreasing myocardial wall tension and improving cardiac oxygen supply. Key Uses & Clinical Benefits: Angina Pectoris Management & Prevention: Reduces the frequency, severity, and duration of angina attacks caused by narrowed or spastic coronary arteries. Flexible Low-Dose Titration: The 5 mg dosage strength allows cardiologists to customize titration schedules, mitigating initial nitrate headaches while achieving targeted anti-ischemic control. Reduces Myocardial Oxygen Demand: Dilates systemic veins to reduce venous return (preload) and lowers systemic vascular resistance (afterload), easing the heart's workload. Adjunctive Heart Failure Support: Used in combination therapy to improve cardiac output and reduce pulmonary capillary wedge pressure in chronic heart failure. Enhances Physical Tolerance: Helps patients with coronary heart disease perform daily light activities with decreased chest discomfort and shortness of breath. How CARDULES ISDN 5 Works: Isosorbide Dinitrate releases Nitric Oxide (NO) in vascular smooth muscle, activating guanylate cyclase to increase cyclic Guanosine Monophosphate (cGMP). Elevated cGMP levels induce smooth muscle relaxation, causing prominent venous dilation, reduced cardiac filling pressures, and enhanced collateral coronary blood flow.
कैसे उपयोग करें
Take 1 tablet of CARDULES ISDN 5 two to three times daily, or strictly as prescribed by your cardiologist or physician. To prevent nitrate tolerance, take doses on an asymmetrical daily schedule (e.g., 8:00 AM and 1:00 PM) to ensure a daily "nitrate-free interval" during rest or sleep. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet unless advised by your doctor.
भंडारण
Store in a cool, dry, and dark place away from direct sunlight, heat, and moisture. Store at a controlled room temperature below 30°C. Keep the bottle or strip tightly closed when not in use. Keep out of reach and sight of children.
