Medicine information
उपयोग
CARDULES ISMN SR 60 by Steris Healthcare provides 60 mg of Isosorbide Mononitrate in an advanced Sustained Release (SR) matrix. Formulated for patients requiring higher-dose vascular protection, this oral organic nitrate delivers controlled, steady medication levels throughout the day to prevent exertional and vasospastic chest pain while strategically guarding against nitrate tolerance. Key Uses & Clinical Benefits: High-Potency Angina Prevention: Effectively manages severe or frequent chronic stable chest pain episodes caused by narrowed or spastic coronary arteries. Advanced Sustained Release Delivery: Delivers a smooth, extended-release profile over several hours, ensuring consistent hemodynamic stability and avoiding sudden blood pressure spikes or drops. Reduces Myocardial Workload: Dilates peripheral veins and arteries, significantly reducing venous return (preload) and systemic vascular resistance (afterload) to lower the heart's oxygen demands. Prevents Nitrate Tolerance: Formulated to support an eccentric once-daily dosing regimen, ensuring an essential daily "nitrate-free interval" to preserve vascular responsiveness. Improves Functional Capacity: Allows patients with severe stable angina to participate in daily physical activities with diminished chest discomfort and breathlessness. How CARDULES ISMN SR 60 Works: Isosorbide Mononitrate is metabolized to generate Nitric Oxide (NO) in vascular smooth muscle cells. Nitric oxide stimulates guanylate cyclase to increase intracellular cyclic Guanosine Monophosphate (cGMP), inducing vascular relaxation. This causes marked venous dilation, reduced cardiac preload, and enhanced blood delivery across collateral coronary vascular beds.
कैसे उपयोग करें
Take 1 tablet of CARDULES ISMN SR 60 once daily in the morning, or strictly as prescribed by your cardiologist or physician. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet, as this destroys the sustained-release delivery system. Taking your dose at the same time every morning ensures a natural nitrate-free period during rest and sleep hours.
भंडारण
Store in a cool, dry, and dark place away from direct sunlight, heat, and moisture. Store at a controlled room temperature below 30°C. Keep out of reach and sight of children.
