Medicine information
उपयोग
SACUSMART 200 by Steris Healthcare delivers a highly effective 200 mg fixed-dose combination of Sacubitril (97 mg) and Valsartan (103 mg) as a sodium salt complex. Engineered as a cornerstone treatment for chronic heart failure with reduced ejection fraction, SACUSMART 200 replaces traditional ACE inhibitors or ARBs to deliver superior reduction in cardiovascular mortality and heart failure hospitalizations by simultaneously boosting beneficial natriuretic peptides and blocking the harmful renin-angiotensin-aldosterone system (RAAS). Key Ingredients & Clinical Benefits: Sacubitril (97 mg): A prodrug that metabolizes into the neprilysin inhibitor LBQ657. By inhibiting the neprilysin enzyme, it stops the degradation of beneficial endogenous natriuretic peptides (ANP and BNP), promoting vasodilation, natriuresis, diuresis, and preventing pathological cardiac remodeling. Valsartan (103 mg): A selective Angiotensin II Receptor Blocker (ARB) that blocks the AT1 receptor. It prevents angiotensin II-mediated vasoconstriction, aldosterone release, sodium retention, and vascular hypertrophy, lowering systemic vascular resistance and cardiac workload. Key Uses & Clinical Benefits: Cornerstone Therapy for Chronic Heart Failure: Significantly reduces cardiovascular death and emergency hospital admissions in patients with heart failure with reduced ejection fraction (HFrEF). Dual Neurohormonal Pathway Blockade: Simultaneously enhances the protective natriuretic peptide system while suppressing the damaging renin-angiotensin-aldosterone system (RAAS). Reverses Cardiac Remodeling: Promotes favorable ventricular remodeling, improves left ventricular ejection fraction (LVEF), and reduces myocardial wall stress. Reduces Cardiac Workload: Promotes smooth vasodilation, decreases systemic vascular resistance, and reduces cardiac preload and afterload. Improves Functional Quality of Life: Reduces fatigue, shortness of breath (dyspnea), and fluid overload symptoms, allowing heart failure patients to engage in daily physical activities.
कैसे उपयोग करें
Take 1 tablet of SACUSMART 200 twice daily (morning and evening), with or without food, or strictly as prescribed by your cardiologist or physician. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet. Adhere strictly to your physician's dosing regimen and do not skip or stop doses abruptly.
भंडारण
Store in a cool, dry, and dark place away from direct sunlight, heat, and moisture. Store at a controlled room temperature below 30°C. Protect from moisture. Keep out of reach and sight of children.
