Medicine information
Uses & overview
NAFTISAFE CREAM 2% by Steris Healthcare delivers 2% w/w of Naftifine Hydrochloride in a soothing, fast-absorbing topical cream base. As a second-generation allylamine antifungal, NAFTISAFE CREAM 2% possesses dual action—exerting direct fungicidal (fungus-killing) activity while providing intrinsic anti-inflammatory properties to calm redness, burning, and severe itching associated with skin ringworm and fungal rashes. Key Ingredients & Clinical Benefits: Naftifine Hydrochloride USP (2% w/w): A potent allylamine antifungal agent that penetrates deep into the stratum corneum (outermost layer of the skin). It provides long-lasting tissue retention, allowing for effective once-daily application with short overall treatment durations. Key Uses & Clinical Benefits: Broad-Spectrum Fungicidal Action: Kills dermatophyte pathogens responsible for ringworm (Tinea corporis), jock itch (Tinea cruris), and athlete's foot (Tinea pedis). Dual Antifungal & Anti-Inflammatory Effect: Rapidly alleviates skin redness, scaling, burning, and intense itching without the need for topical corticosteroids. Once-Daily Convenience: Strong tissue binding and sustained dermal retention allow for simple, once-daily dosing that enhances patient compliance. Targeted Tissue Retention: Concentrates effectively in keratinized skin layers, helping to clear deep-seated dermatophytic infections and reduce relapse rates. Non-Greasy & Soothing Formula: Spreads easily and absorbs cleanly without leaving greasy stains or sticky residues on clothing. How NAFTISAFE CREAM 2% Works: Naftifine selective inhibits the fungal enzyme squalene monooxygenase (squalene epoxidase). This blocks ergosterol biosynthesis and leads to a toxic intracellular accumulation of squalene within fungal cells, causing membrane disruption, cell lysis, and complete fungal eradication.
How to use
Clean and thoroughly dry the affected area and surrounding skin before application. Apply a thin layer of NAFTISAFE CREAM 2% to the affected skin once daily, extending approximately one inch beyond the outer border of the rash, or strictly as directed by your dermatologist or physician. Gently rub in until absorbed. Wash hands thoroughly with soap and water after application. Continue treatment for the full recommended duration to prevent infection recurrence.
Storage
Store in a cool, dry, and dark place away from direct sunlight, heat, and moisture. Store at a controlled room temperature below 25°C. Do not freeze. Keep the tube tightly closed when not in use. Keep out of reach and sight of children.
