Medicine information
Uses & overview
SEIZMET SR 1000 by Steris Healthcare delivers 1000 mg of Metformin Hydrochloride in an advanced Sustained Release (SR) matrix. As the cornerstone therapy for type 2 diabetes, SEIZMET SR 1000 targets hepatic glucose production and cellular insulin resistance without overstimulating pancreatic beta cells. Key Uses & Clinical Benefits: 24-Hour Glycemic Regulation: Effectively lowers both fasting and postprandial (post-meal) blood glucose levels, helping patients maintain consistent HbA1c targets throughout the day. Reduces Hepatic Glucose Output: Inhibits gluconeogenesis and glycogenolysis in the liver, preventing excess sugar from entering the bloodstream. Improves Peripheral Insulin Sensitivity: Enhances glucose uptake and utilization by skeletal muscle and fat tissues, making natural insulin work more efficiently. Enhanced Gastrointestinal Tolerability: The Sustained Release (SR) mechanism delivers the active ingredient gradually over time, significantly reducing common side effects like nausea, bloating, and abdominal discomfort compared to immediate-release formulations. Weight-Neutral & Cardiovascular Support: Supports healthy lipid metabolism and aids in weight management, making it an ideal choice for overweight or obese patients with type 2 diabetes. How SEIZMET SR 1000 Works: Metformin activates AMP-activated protein kinase (AMPK) in hepatic cells, suppressing gluconeogenesis genes and reducing hepatic glucose output. It also decreases intestinal absorption of glucose and improves peripheral cell sensitivity by increasing insulin receptor activity.
How to use
Take 1 tablet of SEIZMET SR 1000 once or twice daily with or immediately after meals (preferably with dinner) or strictly as prescribed by your physician. Taking the tablet with food reduces gastrointestinal side effects. Swallow the tablet whole with a glass of water—do not crush, chew, or break the tablet, as doing so disrupts the sustained-release mechanism.
Storage
Store in a cool, dry place away from direct sunlight, light, and moisture. Store at a controlled room temperature below 30°C. Keep out of reach and sight of children.
